Noticeable differences--check the review.
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The bandage padding extends all the way to the edge on the Band-Aid brand, but is bordered by adhesive on the up&up. Both appear to be made of extremely similar matierials. They feel similar on the skin. The Band-Aid brand may have slightly stronger adhesive. It is also very slightly more easily opened.
These are really similar!
I use the Up and Up brand because I get a lot of blisters from running. They stay on great, even in the shower when I forget to take them off.
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